Data reveal that Niclosamide has pharmacological properties that qualify it for multifunctional application. The drug’s capacity to decouple mitochondrial phosphorylation generally causes these side effects. It may also be utilized to control certain signaling pathways. The drug’s repurposing study suggests that it has a high likelihood of being successful against Parkinson’s disease, diabetes, and viral and microbial infections. It may also be effective against some forms of cancer.
Diabetes
Diabetes affects around one out of every ten persons in the United States. This translates to around 34.2 million individuals suffering from the disease. Prediabetes is a serious condition for one out of every three persons in the United States (88 million). Because metabolic diseases are frequent, it is realistic to expect a plethora of treatment options that would provide positive effects.
Niclosamide in its salt form (known as Niclosamide ethanolamine), which has greater aqueous solubility, has also been shown in mice to improve the symptoms of diabetes Miletus type 2. This therapy, which used mice given a high-fat diet, resulted in increased energy expenditure, improved metabolism, and lipid oxidation. Niclosamide ethanolamine has been shown to be useful in the treatment of high blood sugar (hyperglycemia), glycemic control, and the prevention of disease transmission.
Parkinson’s Illness (PD)
Any aberrant alterations in the catalytic activities of the threonineprotein/mitochondrial serin kinase PINK 1 that have the potential to induce the development of Parkinson’s disease early. The small chemicals that aid this protein’s metabolic functions are known to have neuroprotective qualities. This indicates they might possibly be utilized to treat this condition.
Niclosamide, as a potent activator of the cell’s PINK 1, has a lot of promise for helping to regulate this health issue. However, more PD models will be required to determine whether or not the medication is capable of treating this illness.
Infections caused by viruses
A virus may infect anybody by breathing or eating it. Humans may get the virus via sexual contact or bug bites. People may get infected with viral infections in the upper parts of the nose, throat, and airways. This covers the reproductive, gastric, and neurological systems, among others. Antiviral medications may be used to prevent virus reproduction while preserving the immune system’s firm form. Niclosamide is an excellent candidate for usage as a broad-spectrum antiviral agent. It can target the hosts’ various routes. This activity is related to the product’s ability to eliminate the illness. Many trials have been conducted to far in an effort to employ Niclosamide to treat the Zika, Ebola, and Covid19 viruses.
Infections caused by bacteria
Bacteria, once in the human system, may readily infect the body. This might result in an increase in the number of triggering responses. Bacterial infections may enter humans via the airway or an open wound. Buy niclosamide has shown its promise as an antibacterial agent for treating certain bacterial illnesses. It is most often used to treat TB and MRSA (methicillin-resistant Staphylococcus aureus). Based on these findings, it may be assumed that the substance performs exactly as well as vancomycin, which is currently used to treat MRSA.
Cancer
Cancer has long been studied by medical professionals. Niclosamide has several anticancer characteristics when used to combat the following cancers:
- Colon
- Prostate
- Breast
- Osteosarcoma
- Glioblastoma
- Leukaemia
- Ovarian
- Lung
- Adrenocortical cancer
- Cancers of the mouth
According to the available data, the drug’s capacity to kill a mitochondrial tumor cell and activate apoptosis prevents tumor multiplication in the cell, making it a viable choice.
